Which medication should be monitored closely for renal toxicity when administered?

Which medication should be monitored closely for renal toxicity when administered?

• A. Paclitaxel
• B. Rasburicase
• C. Zoledronic acid
• D. Filgrastim

Answer: (C)

Zoledronic acid should be monitored closely for renal toxicity when administered due to its potential effects on kidney function. This medication, commonly used to treat conditions like hypercalcemia associated with malignancy and for bone metastases, can lead to alterations in renal function, particularly when given in higher doses or in patients with pre-existing kidney impairment. Monitoring renal function is crucial because zoledronic acid is cleared by the kidneys, and any impairment can increase the risk of nephrotoxicity. Regular assessment of serum creatinine and glomerular filtration rate (GFR) is important to ensure the safe administration of this medication. Additionally, hydration status should be monitored, as adequate hydration helps to mitigate potential renal damage. While other medications listed may have specific side effects and monitoring needs, zoledronic acid's direct association with renal function makes it paramount for close scrutiny in patients receiving this treatment.

Zoledronic acid should be monitored closely for renal toxicity when administered due to its potential effects on kidney function. This medication, commonly used to treat conditions like hypercalcemia associated with malignancy and for bone metastases, can lead to alterations in renal function, particularly when given in higher doses or in patients with pre-existing kidney impairment.

Monitoring renal function is crucial because zoledronic acid is cleared by the kidneys, and any impairment can increase the risk of nephrotoxicity. Regular assessment of serum creatinine and glomerular filtration rate (GFR) is important to ensure the safe administration of this medication. Additionally, hydration status should be monitored, as adequate hydration helps to mitigate potential renal damage.

While other medications listed may have specific side effects and monitoring needs, zoledronic acid's direct association with renal function makes it paramount for close scrutiny in patients receiving this treatment.